The Blueprint of Aging

Aging starts in your cells, we target it at the source.

What are the 12 Hallmarks of Aging?

There are 12 fundamental biological processes, called the hallmarks of aging, that underlie how and why we age.

Collectively, they drive the gradual physical and functional decline associated with aging.

Aging starts with your Foundational cracks, builds with Damage, and ends in System Failures you can see and feel.

Foundational

Aging starts with cracks in the foundation

Damage

Aging builds with wear and tear

System Failures

Aging ends in breakdowns you can see and feel

Fixing cellular cracks today helps you avoid system breakdowns tomorrow.

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12 Hallmarks of Aging

Here are the 12 hidden processes inside your body that drive aging and slow you down

Our Formula: Built for All 12

Most supplements target one hallmark, we target them all.

The formula is designed for complete coverage, not just one pathway, and is dosed at human-clinical levels.

Genomic Instability

DNA Damage

DNA Wear and Tear

Ever wonder why our bodies age? One major reason is genomic instability. Our DNA is like the instruction manual for our cells, and over time it collects errors. Think of it like an IKEA manual full of mistakes and missing steps, the final product won’t come together the way it should.

What it Means

DNA is constantly under stress from UV rays, pollution, and even normal cell processes. Over time this leads to mutations, broken strands, and faulty repairs that accumulate inside cells.

Why it Matters

Mutations: Changes in the DNA code that disrupt normal cell activity.
Broken strands: DNA that snaps or frays under stress.
Faulty repairs: The body fixes damage but introduces errors.
These errors build up and cause cells to malfunction, which accelerates aging and increases disease risk.

Top 3 Compounds

Protecting Your DNA

Fuels your body’s natural DNA repair systems.
Boosts NAD⁺, the “battery” molecule that powers cell defense.
Helps cells bounce back from daily stress and damage.
Provides essential building blocks for healthy DNA.
Helps prevent tiny errors that accumulate with age.
Supports brain and cardiovascular health through better cell renewal.
Found in broccoli sprouts, activates your body’s detox pathways.
Shields DNA from toxins and oxidative stress.
Supports long-term cellular resilience.

Top 3 Compounds

Protecting Your DNA

Provides essential building blocks for healthy DNA.
Helps prevent tiny errors that accumulate with age.
Supports brain and cardiovascular health through better cell renewal.

Found in broccoli sprouts, activates your body’s detox pathways.
Shields DNA from toxins and oxidative stress.
Supports long-term cellular resilience.

Fuels your body’s natural DNA repair systems.
Boosts NAD⁺, the “battery” molecule that powers cell defense.
Helps cells bounce back from daily stress and damage.

Telomere Attrition

The Fraying Shoelace

Telomeres are like the plastic tips at the ends of shoelaces, protecting your DNA from unraveling. Each time a cell divides, telomeres get shorter. Eventually, the tips wear down so much that the shoelace, or in this case, the DNA, starts to fall apart.

What it Means

Telomeres shorten naturally as part of aging, but stress, poor lifestyle, and inflammation speed this process up. Once they’re too short, the cell can no longer divide and becomes inactive.

Why it Matters

Cells with critically short telomeres stop renewing.
Linked to weaker immunity and slower tissue repair.
Considered one of the most reliable markers of biological aging.

Chromosome End Damage

Top 3 Compounds

Preserving Your Chromosome Ends

Helps support telomerase, an enzyme linked to longer telomeres.
May slow the natural “shortening clock” of cells.
Backed by early studies showing immune and longevity benefits.
Protects DNA strands so telomeres last longer.
Helps maintain the “caps” that keep chromosomes stable.
Essential for healthy cell growth and renewal.
Associated with longer telomere length in population studies.
Strengthens the immune system and reduces stress on cells.
Supports healthy aging across multiple systems.

Top 3 Compounds

Preserving Your Chromosome Ends

Helps support telomerase, an enzyme linked to longer telomeres.

May slow the natural “shortening clock” of cells.
Backed by early studies showing immune and longevity benefits.

Protects DNA strands so telomeres last longer.
Helps maintain the “caps” that keep chromosomes stable.
Essential for healthy cell growth and renewal.

Associated with longer telomere length in population studies.
Strengthens the immune system and reduces stress on cells.
Supports healthy aging across multiple systems.

Loss of Proteostasis

Protein Buildup

Clogged Cell Machinery

Proteins are like tiny machines that keep your cells running smoothly. But with age, damaged or misshaped proteins pile up. It’s like having a factory floor full of broken machines that no one hauls away; eventually, the whole factory slows down.

What it Means

Normally, the body clears out misfolded proteins. But with aging, that system weakens, and proteins begin clumping together, especially in the brain and muscles.

Why it Matters

Protein clumps block normal cell function.
A key factor in diseases like Alzheimer’s and Parkinson’s.
Accelerates decline in tissue strength and resilience.

Top 3 Compounds

Clearing Damaged Proteins

Activates autophagy, the body’s natural clean-up system.
Helps recycle damaged proteins before they build up.
Linked in human studies to better brain and heart health.
Keeps proteins stable and prevents harmful clumping.
Protects against brain-aging proteins like amyloid.
Strong natural anti-inflammatory support.
Stops proteins from misfolding or sticking together.
Supports the body’s recycling system to clear waste.
Protective in models of brain aging.

Top 3 Compounds

Clearing Damaged Proteins

Activates autophagy, the body’s natural clean-up system.
Helps recycle damaged proteins before they build up.
Linked in human studies to better brain and heart health.

Keeps proteins stable and prevents harmful clumping.
Protects against brain-aging proteins like amyloid.
Strong natural anti-inflammatory support.

Stops proteins from misfolding or sticking together.
Supports the body’s recycling system to clear waste.
Protective in models of brain aging.

Epigenetic Alterations

Gene Switch Malfunction

The Broken Light Switch

Your genes are like thousands of light switches that tell your body when to turn certain functions on or off. With age, these switches get faulty, some stay on when they should be off, and others fail to turn on at all.

What it Means

Epigenetic changes don’t alter your genes themselves, but they change how your genes are read. Over time, this misregulation leads to cells acting older and less efficient.

Why it Matters

Important repair genes can get silenced.
Harmful pathways can become overactive.
Leads to faster aging and higher disease risk.

Top 3 Compounds

Resetting the Body’s Gene Switches

Helps “reset” how your genes are read: a kind of cellular tune-up.
Human research suggests it may make people biologically younger.
Reduces inflammation that disrupts normal gene activity.
Restores NAD⁺, helping genes regulate themselves properly.
Supports energy production and youthful cell behavior.
Clinically shown to improve markers of cell health.
Naturally balances which genes are turned on or off.
Shields DNA from everyday damage.
Linked to better heart, brain, and metabolic health.

Top 3 Compounds

Resetting the Body’s Gene Switches

Helps “reset” how your genes are read: a kind of cellular tune-up.
Human research suggests it may make people biologically younger.
Reduces inflammation that disrupts normal gene activity.

Restores NAD⁺, helping genes regulate themselves properly.
Supports energy production and youthful cell behavior.
Clinically shown to improve markers of cell health.

Naturally balances which genes are turned on or off.
Shields DNA from everyday damage.
Linked to better heart, brain, and metabolic health.
Fun Fact: EGCG is derived from green tea

Disabled Macro-autophagy

Recycling System Breakdown

The City Without Trash Collection

Autophagy is the body’s recycling program: cells break down and reuse old parts to stay efficient. With age, this system slows, like a city where garbage trucks stop coming. Waste piles up, and everything runs worse.

What it Means

Autophagy helps clear out defective proteins and organelles. When this process falters, damaged components accumulate, weakening cells.

Why it Matters

Clogged cells can’t recycle or repair properly.
Energy production suffers.
Accelerates aging across multiple organs.

Top 3 Compounds

Restoring Cellular Recycling

Specifically helps recycle worn-out mitochondria (“cell batteries”).
Clinical trials show improved muscle strength and endurance.
Keeps cells energized and efficient.
Boosts recycling signals inside cells.
Supports lysosomes, the “trash collectors” of the cell.
Adds anti-inflammatory benefits that make recycling more effective.
Turns on your body’s recycling pathways.
Helps cells clear away old or broken parts.
Linked to longer life in animal studies and better cognition in humans.

Top 3 Compounds

Restoring Cellular Recycling

Boosts recycling signals inside cells.
Supports lysosomes, the “trash collectors” of the cell.
Adds anti-inflammatory benefits that make recycling more effective.

Specifically helps recycle worn-out mitochondria (“cell batteries”).
Clinical trials show improved muscle strength and endurance.
Keeps cells energized and efficient.

Turns on your body’s recycling pathways.
Helps cells clear away old or broken parts.
Linked to longer life in animal studies and better cognition in humans.

Deregulated Nutrient Sensing

Metabolic Miscommunication

The Broken Thermostat

Nutrient-sensing pathways are like a thermostat for energy — deciding when to grow, conserve, or repair. With age, the thermostat malfunctions, and cells misread the body’s nutrient signals.

What it Means

Over time, nutrient-sensing pathways like insulin and mTOR get out of sync, leading to miscommunication about how the body should use energy.

Why it Matters

Drives weight gain and insulin resistance.
Over-activates growth pathways that speed aging.
Reduces energy efficiency across the body.

Top 3 Compounds

Resetting Metabolic Balance

Mimics calorie restriction benefits without dieting.
Improves blood sugar control and insulin sensitivity.
Helps rebalance energy-sensing pathways linked to longevity.
Influences nutrient-sensing systems like mTOR.
Extends healthy lifespan in animal studies.
Buffers against metabolic stress and overload.
Boosts NAD⁺ to activate sirtuins, “longevity regulators” of metabolism.
Supports healthy mitochondria for better energy balance.
Improves markers of metabolic health in human trials.

Top 3 Compounds

Resetting Metabolic Balance

Mimics calorie restriction benefits without dieting.
Improves blood sugar control and insulin sensitivity.
Helps rebalance energy-sensing pathways linked to longevity.

Boosts NAD⁺ to activate sirtuins, “longevity regulators” of metabolism.
Supports healthy mitochondria for better energy balance.
Improves markers of metabolic health in human trials.

Influences nutrient-sensing systems like mTOR.
Extends healthy lifespan in animal studies.
Buffers against metabolic stress and overload.

Mitochondrial Dysfunction

Powerhouse Decline

The Fading Batteries

Mitochondria are your cell’s batteries, powering movement, thinking, and repair. With age, they start producing less energy and more harmful byproducts, like a battery that leaks acid instead of holding a charge.

What it Means

As mitochondria break down, cells struggle to power their basic functions. The damage also spreads oxidative stress throughout the body.

Why it Matters

Causes fatigue and slower recovery.
Weakens brain, muscle, and heart performance.
Fuels other hallmarks like inflammation and cell death.

Top 3 Compounds

Recharging the Cell’s Powerhouses

Antioxidant that protects mitochondria from stress.
More bioavailable than resveratrol, a similar compound.
Shown to support brain and metabolic health in aging models.
Stimulates recycling of old, faulty mitochondria.
Human trials show better muscle endurance and energy production.
Protects cells from mitochondrial decline with age.
Restores NAD⁺ to keep mitochondria running efficiently.
Helps create new, healthy mitochondria.
Supports recovery and energy in muscles and tissues.

Top 3 Compounds

Recharging the Cell’s Powerhouses

Stimulates recycling of old, faulty mitochondria.
Human trials show better muscle endurance and energy production.
Protects cells from mitochondrial decline with age.

Restores NAD⁺ to keep mitochondria running efficiently.
Helps create new, healthy mitochondria.
Supports recovery and energy in muscles and tissues.

Antioxidant that protects mitochondria from stress.
More bioavailable than resveratrol, a similar compound.
Shown to support brain and metabolic health in aging models.

Cellular Senescence

Zombie Cells

The Bad Neighbors

Sometimes cells stop dividing but refuse to die. Instead, they hang around like bad neighbors, blasting toxic signals that damage the whole block.

What it Means

These “zombie cells” release harmful molecules called SASPs, which spread inflammation and disrupt healthy tissue.

Why it Matters

Build up more and more with age.
Linked to arthritis, heart disease, and skin aging.
Block tissue repair and accelerate decline.

Top 3 Compounds

Removing “Zombie Cells”

Helps clear senescent “zombie” cells that drive aging.
Extends lifespan in animal studies.
Reduces harmful inflammation from old cells.
Works with fisetin to target zombie cells.
Early human trials suggest reduced senescence burden.
Also supports circulation and heart health.
Naturally slows pro-senescence signals.
Supports healthy cellular turnover.
Adds neuroprotective and calming benefits.

Top 3 Compounds

Removing “Zombie Cells”

Helps clear senescent “zombie” cells that drive aging.
Extends lifespan in animal studies.
Reduces harmful inflammation from old cells.

Works with fisetin to target zombie cells.
Early human trials suggest reduced senescence burden.
Also supports circulation and heart health.

Naturally slows pro-senescence signals.
Supports healthy cellular turnover.
Adds neuroprotective and calming benefits.

Stem Cell Exhaustion

Repair System Failure

The Retired Workforce

Stem cells are the body’s repair crew, always ready to replace damaged cells. But with age, this workforce shrinks and becomes less capable, leaving tissues with no one to fix the damage.

What it Means

Stem cells lose energy and numbers over time, reducing their ability to regenerate skin, muscles, blood, and other tissues.

Why it Matters

Healing slows after injury.
Muscles, skin, and immune defenses weaken.
A major driver of frailty and age-related decline.

Top 3 Compounds

Preserving the Body’s Renewal System

Helps stem cells stay youthful and active.
Linked to longer healthspan and vitality.
Supports tissue repair across the body.
Provides NAD⁺ fuel that stem cells need to self-renew.
Protects against stem cell fatigue with age.
Promotes stronger tissue regeneration.
Keeps stem cells active by boosting recycling systems.
Shown to preserve blood and immune stem cells.
Enhances natural repair processes.

Top 3 Compounds

Preserving the Body’s Renewal System

Helps stem cells stay youthful and active.

Linked to longer healthspan and vitality.
Supports tissue repair across the body.

Provides NAD⁺ fuel that stem cells need to self-renew.
Protects against stem cell fatigue with age.
Promotes stronger tissue regeneration.

Keeps stem cells active by boosting recycling systems.
Shown to preserve blood and immune stem cells.
Enhances natural repair processes.

Altered Intercellular Communication

Mixed Signals System

Static on the Line

Cells need clear communication to stay in sync, like radios on the same frequency. With age, the signals get scrambled, creating static that confuses cells and organs.

What it Means

Aging cells release distorted signals that spread stress and inflammation throughout the body.

Why it Matters

Weakens the immune system.
Fuels chronic inflammation.
Disrupts balance between tissues and organs.

Top 3 Compounds

Restoring Healthy Cell Signaling

Stabilizes stress-related cell signals.
Associated with longer life in population studies.
Supports brain and mood health.
Adaptogen that helps balance stress hormones.
Supports energy, focus, and mental clarity.
Reduces the impact of everyday stress on cells.
Enhances immune and neuronal communication.
Improves coordination between cells under stress.
Linked to better brain function.

Top 3 Compounds

Restoring Healthy Cell Signaling

Adaptogen that helps balance stress hormones.
Supports energy, focus, and mental clarity.
Reduces the impact of everyday stress on cells.

Stabilizes stress-related cell signals.
Associated with longer life in population studies.
Supports brain and mood health.

Enhances immune and neuronal communication.
Improves coordination between cells under stress.
Linked to better brain function.

Chronic Inflammation

Inflammaging - The Fire That Won’t Go Out

The Smoldering Fire

Inflammation is good in short bursts: it heals cuts and fights infections. But with age, the body often slips into a constant low-grade inflammation, like a fire that never burns out.

What it Means

This “inflammaging” damages tissues slowly and silently, affecting the entire body.

Why it Matters

Fuels heart disease, diabetes, and dementia.
Weakens healthy tissue over time.
Makes other hallmarks of aging worse.

Top 3 Compounds

Cooling the Fire of “Inflammaging”

One of nature’s strongest anti-inflammatory compounds.
Helps with joint comfort and cardiovascular health.
Protects against low-grade, chronic inflammation that accelerates aging.
From green tea, naturally reduces inflammatory signals.
Supports brain and heart health.
Improves circulation and lowers oxidative stress.
Senolytic action removes old, inflammation-driving cells.
Strong antioxidant for brain and blood vessel protection.
Extends lifespan in animal studies.

Top 3 Compounds

Cooling the Fire of “Inflammaging”

One of nature’s strongest anti-inflammatory compounds.
Helps with joint comfort and cardiovascular health.
Protects against low-grade, chronic inflammation that accelerates aging.

From green tea, naturally reduces inflammatory signals.
Supports brain and heart health.
Improves circulation and lowers oxidative stress.

Senolytic action removes old, inflammation-driving cells.
Strong antioxidant for brain and blood vessel protection.
Extends lifespan in animal studies.

Dysbiosis

Gut Microbiome Imbalance

The Unbalanced Ecosystem

Your gut is home to trillions of bacteria that act like a rainforest ecosystem. With age, harmful species overgrow while helpful ones decline, throwing the system off balance.

What it Means

This imbalance, called dysbiosis, weakens the gut’s ability to support digestion, immunity, and whole-body health.

Why it Matters

Increases inflammation and “leaky gut.”
Disrupts metabolism and nutrient absorption.
Affects immunity, mood, and brain health.

Top 3 Compounds

Balancing the Gut Microbiome

Helps shape a healthier gut microbiome.
Supports blood sugar and metabolic health.
Protects the gut lining from damage.
Reduces gut inflammation and supports healthy digestion.
Encourages beneficial gut bacteria.
Adds whole-body anti-inflammatory benefits.
Boosts gut antioxidant defenses.
Helps detox harmful compounds in the gut.
Supports a strong gut barrier and balanced microbiome.

Top 3 Compounds

Balancing the Gut Microbiome

Helps shape a healthier gut microbiome.
Supports blood sugar and metabolic health.
Protects the gut lining from damage.

Reduces gut inflammation and supports healthy digestion.
Encourages beneficial gut bacteria.
Adds whole-body anti-inflammatory benefits.

Boosts gut antioxidant defenses.
Helps detox harmful compounds in the gut.
Supports a strong gut barrier and balanced microbiome.

Aging starts in your cells.

Take Control

Hallmark Deep Dive

Genomic Instability

Plain English: DNA damage builds up over time, like typos in your body’s instruction manual.
Why It Matters: Damaged DNA can cause faulty proteins, mutations, and loss of proper cell function, which accelerates aging and disease risk.
Telomere Attrition

Plain English: The protective caps on your chromosomes (telomeres) get shorter every time cells divide.
Why It Matters: When telomeres become too short, cells stop dividing or die, contributing to tissue aging.
Loss of Proteostasis

Plain English: Your cells lose the ability to fold, repair, and recycle proteins correctly.
Why It Matters: Misfolded proteins can clump together, damaging cells and contributing to neurodegeneration and other age-related diseases.
Epigenetic Alterations

Plain English: The “on/off switches” that control your genes get scrambled over time.
Why It Matters: Changes in gene expression can cause cells to act older or malfunction, even if the DNA sequence is fine.
Disabled Macroautophagy

Plain English: Your cells’ cleanup and recycling system slows down.
Why It Matters: Old and damaged components pile up, impairing cell function and increasing inflammation.
Deregulated Nutrient Sensing

Plain English: Your cells can’t properly detect and respond to nutrients and energy signals.
Why It Matters: Disrupted nutrient sensing accelerates aging and metabolic decline, contributing to obesity, diabetes, and reduced lifespan.
Mitochondrial Dysfunction

Plain English: Your cells’ power plants (mitochondria) produce less energy and more harmful byproducts.
Why It Matters: Energy decline in cells causes fatigue, slower repair, and organ aging.
Cellular Senescence

Plain English: Some cells stop dividing but don’t die — they just sit there releasing harmful chemicals.
Why It Matters: These “zombie cells” promote inflammation and damage nearby healthy cells.
Stem Cell Exhaustion

Plain English: Your reserve of repair cells runs low or becomes less effective.
Why It Matters: Tissues can’t regenerate as quickly, slowing healing and maintenance.
Altered Intercellular Communication

Plain English: Cells send the wrong signals or stop “talking” effectively to each other.
Why It Matters: This miscommunication drives chronic inflammation and disrupts tissue coordination.
Chronic Inflammation (Inflammaging)

Plain English: Low-grade, persistent inflammation slowly damages tissues and accelerates aging.
Why It Matters: Inflammaging is linked to almost every chronic disease of aging.
Dysbiosis

Plain English: The community of microbes in your gut shifts in unhealthy ways.
Why It Matters: A disrupted microbiome promotes inflammation, nutrient absorption issues, and immune dysfunction.